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A Study of Combination Nivolumab and Ipilimumab Retreatment in Patients with Advanced Kidney Cancer

Trial ID: NCT04088500
Kidney Cancer Type: Any


Background:

Nivolumab (Opdivo®) is an immunotherapy drug that is already approved for the treatment of advanced kidney cancer in Canada. It works by targeting a molecule called PD-1 to reactivate the body’s own immune response to target and destroy cancer cells.

Nivolumab is often combined with another drug called Ipilimumab (Yervoy®). This is another type of immunotherapy which targets a molecule called CTLA-4 and allows the body to increase the number of immune cells available to attack and destroy cancer cells.

Under the right circumstances, these drugs have been shown to be more effective when taken together than when taken separately.


The Trial:

This study will investigate whether the combination of Nivolumab and Ipilimumab can be used in patients a second time, even after they have already stopped responding to the treatment at an earlier time point.

This is a single-group study, so there is no randomization, no placebo, and all patients will receive treatment.


Basic Eligibility:

  • All subtypes eligible
  • Patient must have received and subsequently stopped responding to Ipilimumab/Nivolumab treatment

Additional eligibility criteria will apply. Please speak to your doctor.

 

Find out more about this study.
Hospital / Cancer CentrePrincipal InvestigatorLocationTrial Status
Hospital / Cancer CentreBC Cancer Agency - Vancouver Centre Principal InvestigatorDr. Christian Kollmannsberger LocationVancouver, BC Trial StatusRecruiting
Hospital / Cancer CentreTom Baker Cancer Centre Principal InvestigatorDr. Daniel Heng LocationCalgary, AB Trial StatusPending
Hospital / Cancer CentreCross Cancer Institute Principal InvestigatorDr. Naveen Basappa LocationEdmonton, AB Trial StatusRecruiting
Hospital / Cancer CentreJuravinski Cancer Centre Principal InvestigatorDr. Sébastien Hotte LocationHamilton, ON Trial StatusRecruiting
Hospital / Cancer CentreSunnybrook Health Sciences Centre Principal InvestigatorDr. Georg Bjarnason LocationToronto, ON Trial StatusRecruiting
Hospital / Cancer CentrePrincess Margaret Cancer Center Principal InvestigatorDr. Aaron Hansen LocationToronto, ON Trial StatusRecruiting
Hospital / Cancer CentreCentre hospitalier de l'Université de Montréal - CHUM Principal InvestigatorDr. Denis Soulières LocationMontreal, QC Trial StatusRecruiting
Hospital / Cancer CentreJewish General Hospital Principal InvestigatorDr. Wilson Miller LocationMontreal, QC Trial StatusRecruiting
Hospital / Cancer CentreHôtel-Dieu de Québec Principal InvestigatorDr. Vincent Castonguay LocationQuebec City, QC Trial StatusRecruiting
Hospital / Cancer CentreCIUSSS de l'Estrie - CHUS Principal InvestigatorDr. Michel Pavic LocationSherbrooke, QC Trial StatusRecruiting
Hospital / Cancer CentreQEII Health Sciences Centre Principal InvestigatorDr. Lori Wood LocationHalifax, NS Trial StatusRecruiting
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