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A Study of Post-Surgery Treatment Options for Children With Stage I–III Wilms’ Tumor

Trial ID: NCT00352534
Kidney Cancer Type: Wilms’ tumor


Background:

Chemotherapy uses strong medicines to kill cancer cells or stop them from growing. In this study, patients may receive several different chemotherapy drugs that work in different ways. Vincristine stops cancer cells from dividing and spreading. Dactinomycin blocks the instructions cancer cells need to grow. Doxorubicin damages the DNA inside cancer cells, which helps destroy them.

Radiotherapy uses high-energy x-rays to shrink or kill any remaining cancer cells.


The Trial:

This study is looking at the best way to treat children with Wilms’ tumor after surgery.

Based on the stage and features of their cancer, each child will be placed into a treatment group. 

The treatment groups may include:

  • Chemotherapy (using vincristine, dactinomycin, and doxorubicin)
  • Radiation therapy
  • Observation only (watching the patient closely after surgery without giving more treatment unless it becomes necessary)

The trial is not “blind”, so both you and your doctor will know which therapy you are receiving. 


Basic Eligibility:

  • Children and young adults up to 30 years old
  • Stage I, II, or III Wilms’ tumor
  • Already had surgery to remove the tumor 

Additional eligibility criteria will apply. Please speak to your doctor.

Find out more about this study.
Hospital / Cancer CentrePrincipal InvestigatorLocationTrial Status
Hospital / Cancer CentreAlberta Children’s Hospital Principal InvestigatorNot Given LocationCalgary, AB Trial StatusActive, not recruiting
Hospital / Cancer CentreUniversity of Alberta Hospital Principal InvestigatorNot Given LocationEdmonton, AB Trial StatusActive, not recruiting
Hospital / Cancer CentreBritish Columbia Children’s Hospital Principal InvestigatorNot Given LocationVancouver, BC Trial StatusActive, not recruiting
Hospital / Cancer CentreCancerCare Manitoba Principal InvestigatorNot Given LocationWinnipeg, MB Trial StatusActive, not recruiting
Hospital / Cancer CentreJaneway Child Health Centre Principal InvestigatorNot Given LocationSaint John’s, NL Trial StatusActive, not recruiting
Hospital / Cancer CentreIWK Health Centre Principal InvestigatorNot Given LocationHalifax, NS Trial StatusActive, not recruiting
Hospital / Cancer CentreMcMaster Children’s Hospital at Hamilton Health Sciences Principal InvestigatorNot Given LocationHamilton, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreKingston Health Sciences Centre Principal InvestigatorNot Given LocationKingston, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreChildren’s Hospital Principal InvestigatorNot Given LocationLondon, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreVictoria Hospital Principal InvestigatorNot Given LocationLondon, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreChildren’s Hospital of Eastern Ontario Principal InvestigatorNot Given LocationOttawa, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreHospital for Sick Children Principal InvestigatorNot Given LocationToronto, ON Trial StatusActive, not recruiting
Hospital / Cancer CentreAllan Blair Cancer Centre Principal InvestigatorNot Given LocationRegina, SK Trial StatusActive, not recruiting
Hospital / Cancer CentreSaskatoon Cancer Centre Principal InvestigatorNot Given LocationSaskatoon, SK Trial StatusActive, not recruiting
Hospital / Cancer CentreCHU de Quebec-Centre Hospitalier de l’Universite Laval (CHUL) Principal InvestigatorNot Given LocationQuebec, QC Trial StatusActive, not recruiting
Hospital / Cancer CentreThe Montreal Children’s Hospital of the MUHC Principal InvestigatorNot Given LocationMontreal, QC Trial StatusActive, not recruiting
Hospital / Cancer CentreCentre Hospitalier Universitaire Sainte-Justine Principal InvestigatorNot Given LocationMontreal, QC Trial StatusActive, not recruiting
Kidney Cancer Canada