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Kidney Cancer Trials in Canada

Diagnostic / Imaging Trials

Diagnostic trials look at what tests (such as blood, laboratory or imaging tests), or procedures are best at finding (detecting) kidney cancer or seeing if kidney cancer has come back (recurred).

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Prognostic / Predictive Trials

Studies may be done to look at certain factors or characteristics of a patient or their cancer cells that provide information on the likely outcome (prognosis) of a patient with kidney cancer. Studies may also be done to see what might predict how a kidney cancer patient will respond to treatment (predictive factor).

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Active Surveillance Trials

Active surveillance uses a watch-and-wait approach, keeping a close watch on a patient’s kidney cancer, but waiting to start treatment until it starts to grow or cause problems.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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After Surgery (Adjuvant) Treatment Trials

The purpose of adjuvant trials is to find out whether additional treatment given after kidney cancer surgery – which is the main treatment for kidney cancer – helps slow or reduce the risk of cancer coming back. Types of adjuvant treatments include drug therapy, radiation therapy or sometimes other treatments.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Before Surgery (Neoadjuvant) Treatment Trials

Neoadjuvant trials test whether certain treatments given before the main treatment, which is usually surgery, help reduce the size of kidney tumours. Types of neoadjuvant treatments include drug therapy, radiation therapy or other treatments.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Drug Treatment Trials

Drug trials test a new drug, different combinations of drugs, or using different dosages and schedules for giving drugs to better treat patients with kidney cancer. Drug trials also test how safe, effective and what side effects a new drug or combination of drugs may have.

Because most kidney cancers do not respond well to chemotherapy, these studies often focus on using new or different combinations of drugs, such as targeted or immuno-oncology therapies. The studies listed below are mainly for patients whose cancer has spread from where it started in the kidney to nearby tissue or lymph nodes (locally advanced) or spread to other parts of the body (metastatic) kidney cancer.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Radiation Treatment Trials

Radiation therapy trials test different ways of giving radiation or combining radiation with other cancer treatments to better treat patients with kidney cancer.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned.

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Supportive Care Trials

Supportive care trials look at ways to improve the quality of life of kidney cancer patients and how best to manage the symptoms of cancer or side effects of treatment. These trials study new ways of helping kidney cancer patients cope with pain, problems with nutrition, diarrhea, nausea, and other health problems. Some of these trials may test drugs or might use different types of activities to see their effect on the patient living with kidney cancer and if their quality of life is improved.

Note: When available, the researcher in charge of the study, called the Principal Investigator, is listed. Also, if the clinical trial is for a particular type of cancer it will be mentioned

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