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A Study of Combination Chemotherapy in Patients with Wilms Tumours

Trial ID: NCT04322318
Kidney Cancer Type: Wilms' Tumour


Background:

Wilms tumour is a rare type of kidney cancer that primarily affects children. For most patients, the first line of treatment is surgery to remove the affected kidney (nephrectomy). This may be accompanied by either radiation treatment, chemotherapy, or both, depending on the size and stage of the tumour.

At present, there are six different chemotherapy “regimens” that may be used in the treatment of Wilms tumour. These regimens consist of a series of chemotherapy drugs (2-6) that attack the tumour in a variety of different ways.  The most appropriate regimen is selected by a medical oncologist based on an assessment of the pathology and stage of the tumor.

In this trial, the researchers will be studying two new regimens of chemotherapy for the treatment of Wilms tumour:

  1. Regimen UH-3: Vincristine, Doxorubicin, Cyclophosphamide, Carboplatin, Etoposide, and Irinotecan
  2. ICE/Cyclo/Topo: Ifosfamide, Carboplatin, Etoposide, Cyclophosphamide, and Topotecan


The Trial:
This study will be divided into two treatment groups that will be assigned by the physician handling your care:

Group 1 will received Regimen UH-3
Group 2 will receive the ICE/Cyclo/Topo regimen

The medications will be administered by IV (to a vein in the arm) in a specific order for each regimen.

There is no control group in the study, so there will be no “placebo”, and all patients will receive treatment.


Basic Eligibility:

  • Newly diagnosed stage 2/3/4 diffuse anaplastic Wilms tumour, or;
  • Favourable histology Wilms tumour that has returned after previously achieving remission

Additional eligibility criteria will apply. Please speak to your doctor.

 

Find out more about this study.
Hospital / Cancer CentrePrincipal InvestigatorLocationTrial Status
Hospital / Cancer CentreBritish Columbia Children's Hospital Principal InvestigatorDavid Dix LocationVancouver, BC Trial StatusRecruiting
Hospital / Cancer CentreAlberta Children's Hospital Principal InvestigatorDouglas R. Strother LocationCalgary, AB Trial StatusRecruiting
Hospital / Cancer CentreCancerCare Manitoba Principal InvestigatorAshley Chopek LocationWinnipeg, MB Trial StatusRecruiting
Hospital / Cancer CentreCentre Hospitalier Universitaire Sainte-Justine Principal InvestigatorYvan Samson LocationMontreal, QC Trial StatusRecruiting
Hospital / Cancer CentreThe Montreal Children's Hospital of the MUHC Principal InvestigatorSharon Abish LocationMontreal, QC Trial StatusRecruiting
Hospital / Cancer CentreCentre Hospitalier Universitaire de Quebec Principal InvestigatorBruno Michon LocationQuébec, QC Trial StatusRecruiting
Hospital / Cancer CentreMcMaster Children's Hospital at Hamilton Health Sciences Principal InvestigatorUma Athale LocationHamilton, ON Trial StatusRecruiting
Hospital / Cancer CentreChildren's Hospital Principal InvestigatorShayna Zelcer LocationLondon, ON Trial StatusRecruiting
Hospital / Cancer CentreChildren's Hospital of Eastern Ontario Principal InvestigatorDonna Johnston LocationOttawa, ON Trial StatusRecruiting
Hospital / Cancer CentreHospital for Sick Children Principal InvestigatorDaniel Morgenstern LocationToronto, ON Trial StatusRecruiting
Hospital / Cancer CentreIWK Health Centre Principal InvestigatorCraig Erker LocationHalifax, NS Trial StatusRecruiting
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