Background:
Wilms’ tumor is a type of kidney cancer that mostly affects children. This study is for patients who have been recently diagnosed with stage III or stage IV Wilms’ tumor, which means the cancer has spread beyond the kidney.
Chemotherapy uses strong medicines to kill cancer cells or stop them from growing. In this study, patients may receive several different chemotherapy drugs that work in different ways. Vincristine stops cancer cells from dividing and spreading. Dactinomycin blocks the instructions cancer cells need to grow. Doxorubicin damages the DNA inside cancer cells, which helps destroy them. Cyclophosphamide is a powerful medicine that also damages cancer cell DNA and is often used when a stronger treatment is needed. Using these drugs together can be more effective because each one targets cancer cells in a different way.
Radiation therapy may also be added to the treatment plan, using high-energy x-rays to destroy cancer cells.
The Trial:
This study is looking at how well combination chemotherapy with or without radiation therapy works to treat stage III or IV Wilms’ tumor after surgery.
All participants will be receiving the same treatment.
Treatment drugs/interventions include:
- Vincristine
- Dactinomycin
- Doxorubicin
- Cyclophosphamide
- Radiation therapy
The trial is not “blind”, so both you and your doctor will know which therapy you are receiving.
Basic Eligibility:
-
- Up to 29 years old
- recently diagnosed with stage III or stage IV Wilms’ tumor
- Treatment must start within 14 days after surgery or biopsy
Additional eligibility criteria will apply. Please speak to your doctor.
Hospital / Cancer Centre | Principal Investigator | Location | Trial Status |
---|---|---|---|
Hospital / Cancer CentreAlberta Children’s Hospital | Principal InvestigatorNot Given | LocationCalgary, AB | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreUniversity of Alberta Hospital | Principal InvestigatorNot Given | LocationEdmonton, AB | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreBritish Columbia Children’s Hospital | Principal InvestigatorNot Given | LocationVancouver, BC | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreCancerCare Manitoba | Principal InvestigatorNot Given | LocationWinnipeg, MB | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreJaneway Child Health Centre | Principal InvestigatorNot Given | LocationSaint John’s, NL | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreIWK Health Centre | Principal InvestigatorNot Given | LocationHalifax, NS | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreMcMaster Children’s Hospital at Hamilton Health Sciences | Principal InvestigatorNot Given | LocationHamilton, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreKingston Health Sciences Centre | Principal InvestigatorNot Given | LocationKingston, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreChildren’s Hospital | Principal InvestigatorNot Given | LocationLondon, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreVictoria Hospital | Principal InvestigatorNot Given | LocationLondon, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreChildren’s Hospital of Eastern Ontario | Principal InvestigatorNot Given | LocationOttawa, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreHospital for Sick Children | Principal InvestigatorNot Given | LocationToronto, ON | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreSaskatoon Cancer Centre | Principal InvestigatorNot Given | LocationSaskatoon, SK | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreCHU de Quebec-Centre Hospitalier de l’Universite Laval (CHUL) | Principal InvestigatorNot Given | LocationQuebec, QC | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreThe Montreal Children’s Hospital of the MUHC | Principal InvestigatorNot Given | LocationMontreal, QC | Trial StatusActive, Not Recruiting |
Hospital / Cancer CentreCentre Hospitalier Universitaire Sainte-Justine | Principal InvestigatorNot Given | LocationMontreal, QC | Trial StatusActive, Not Recruiting |