1-866-598-7166

Combination Chemotherapy With or Without Radiation for Advanced Wilms’ Tumor

Trial ID: NCT00379340
Kidney Cancer Type: Wilms’ tumor


Background:

Wilms’ tumor is a type of kidney cancer that mostly affects children. This study is for patients who have been recently diagnosed with stage III or stage IV Wilms’ tumor, which means the cancer has spread beyond the kidney.

Chemotherapy uses strong medicines to kill cancer cells or stop them from growing. In this study, patients may receive several different chemotherapy drugs that work in different ways. Vincristine stops cancer cells from dividing and spreading. Dactinomycin blocks the instructions cancer cells need to grow. Doxorubicin damages the DNA inside cancer cells, which helps destroy them. Cyclophosphamide is a powerful medicine that also damages cancer cell DNA and is often used when a stronger treatment is needed. Using these drugs together can be more effective because each one targets cancer cells in a different way.

Radiation therapy may also be added to the treatment plan, using high-energy x-rays to destroy cancer cells.


The Trial:

This study is looking at how well combination chemotherapy with or without radiation therapy works to treat stage III or IV Wilms’ tumor after surgery.

All participants will be receiving the same treatment. 

Treatment drugs/interventions include:

  • Vincristine
  • Dactinomycin
  • Doxorubicin
  • Cyclophosphamide
  • Radiation therapy

The trial is not “blind”, so both you and your doctor will know which therapy you are receiving.

 

Basic Eligibility:

    • Up to 29 years old
    • recently diagnosed with stage III or stage IV Wilms’ tumor
    • Treatment must start within 14 days after surgery or biopsy

Additional eligibility criteria will apply. Please speak to your doctor.

Find out more about this study.
Hospital / Cancer CentrePrincipal InvestigatorLocationTrial Status
Hospital / Cancer CentreAlberta Children’s Hospital Principal InvestigatorNot Given LocationCalgary, AB Trial StatusActive, Not Recruiting
Hospital / Cancer CentreUniversity of Alberta Hospital Principal InvestigatorNot Given LocationEdmonton, AB Trial StatusActive, Not Recruiting
Hospital / Cancer CentreBritish Columbia Children’s Hospital Principal InvestigatorNot Given LocationVancouver, BC Trial StatusActive, Not Recruiting
Hospital / Cancer CentreCancerCare Manitoba Principal InvestigatorNot Given LocationWinnipeg, MB Trial StatusActive, Not Recruiting
Hospital / Cancer CentreJaneway Child Health Centre Principal InvestigatorNot Given LocationSaint John’s, NL Trial StatusActive, Not Recruiting
Hospital / Cancer CentreIWK Health Centre Principal InvestigatorNot Given LocationHalifax, NS Trial StatusActive, Not Recruiting
Hospital / Cancer CentreMcMaster Children’s Hospital at Hamilton Health Sciences Principal InvestigatorNot Given LocationHamilton, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreKingston Health Sciences Centre Principal InvestigatorNot Given LocationKingston, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreChildren’s Hospital Principal InvestigatorNot Given LocationLondon, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreVictoria Hospital Principal InvestigatorNot Given LocationLondon, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreChildren’s Hospital of Eastern Ontario Principal InvestigatorNot Given LocationOttawa, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreHospital for Sick Children Principal InvestigatorNot Given LocationToronto, ON Trial StatusActive, Not Recruiting
Hospital / Cancer CentreSaskatoon Cancer Centre Principal InvestigatorNot Given LocationSaskatoon, SK Trial StatusActive, Not Recruiting
Hospital / Cancer CentreCHU de Quebec-Centre Hospitalier de l’Universite Laval (CHUL) Principal InvestigatorNot Given LocationQuebec, QC Trial StatusActive, Not Recruiting
Hospital / Cancer CentreThe Montreal Children’s Hospital of the MUHC Principal InvestigatorNot Given LocationMontreal, QC Trial StatusActive, Not Recruiting
Hospital / Cancer CentreCentre Hospitalier Universitaire Sainte-Justine Principal InvestigatorNot Given LocationMontreal, QC Trial StatusActive, Not Recruiting
Kidney Cancer Canada