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Stereotactic Body Radiation Therapy (SBRT) with Ipilimumab and Nivolumab for Advanced Kidney Cancer (CYTOSHRINK)

Trial ID: NCT04090710
Kidney Cancer Type: Any


Background:

Stereotactic Body Radiation Therapy (SBRT) is used to treat cancers using substantially higher doses of radiation than conventional radiotherapy. This technology is able to deliver higher doses of radiation to a tumour, while limiting the dose of radiation to nearby normal tissues.

The drugs used in this study are Ipilimumab (Yervoy®) and Nivolumab (Opdivo®), which are immunotherapy drugs that work by reactivating the body’s own immune response to target and destroy cancer cells. In combination, Ipilimumab and Nivolumab are Health Canada-approved for the treatment of advanced kidney cancer.


The Trial:

This study will investigate the safety and effectiveness of combining SBRT with Ipilimumab and Nivolumab. Specifically, the researchers will test whether SBRT can improve a patient’s response to treatment with Ipilimumab and Nivolumab.

Patients on this trial will be randomly assigned to one of two groups:
1.  Ipilimumab and Nivolumab only
2. SBRT followed by Ipilimumab and Nivolumab


Basic Eligibility:

  • All subtypes eligible
  • No prior systematic therapy is permitted
  • Cancer must have spread beyond the kidney
  • Cancer cannot be removed by surgery

Additional eligibility criteria will apply. Please speak to your doctor.

 

Find out more about this study.
Hospital / Cancer CentrePrincipal InvestigatorLocationTrial Status
Hospital / Cancer CentreCross Cancer Institute Principal InvestigatorDr. Naveen Basappa LocationEdmonton, AB Trial StatusNot Yet Recruiting
Hospital / Cancer CentreJuravinski Cancer Centre Principal InvestigatorDr. Aly-Khan Lalani LocationHamilton, ON Trial StatusRecruiting
Hospital / Cancer CentreGrand River Regional Cancer Centre Principal Investigator LocationKitchener, ON Trial StatusNot Yet Recruiting
Hospital / Cancer CentreLondon Regional Cancer Centre Principal InvestigatorDr. Eric Winquist LocationLondon, ON Trial StatusNot Yet Recruiting
Hospital / Cancer CentreThe Ottawa Regional Cancer Centre Principal InvestigatorDr. Scott Morgan LocationOttawa, ON Trial StatusRecruiting
Hospital / Cancer CentreSunnybrook Health Sciences Centre- Odette Cancer Centre Principal InvestigatorDr. William Chu LocationToronto, ON Trial StatusRecruiting
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