Combination therapy: Lenvatinib+Pembrolizumab

The provinces of Alberta and Quebec have added pembrolizumab in combination with lenvatinib to their drug formularies for the first-line treatment of adult patients with advanced or metastatic renal cell carcinoma (RCC). Eligible patients should be previously untreated in the metastatic setting and have a good performance status.

Pembrolizumab treatment should continue until confirmed disease progression or unacceptable toxicity to a maximum of 2 years, whichever comes first. Lenvatinib treatment should continue until disease progression or unacceptable toxicity.


Access to medication by province
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